# Automated Dry Heat Diffusion System

Canonical: https://abierto.us/opportunities/75f40125q00181

- Solicitation number: 75F40125Q00181
- Notice type: Combined synopsis and solicitation
- Status: Awarded to Aantilia LLC
- Department: Department of Health and Human Services
- Agency: Food and Drug Administration
- Contracting office: FDA Office of Acq Grant SVCS (75F401)
- NAICS: 334516 Analytical Laboratory Instrument Manufacturing
- Product or service code: 6640 Laboratory Equipment and Supplies
- Place of performance: Silver Spring, Maryland
- County: Montgomery County (FIPS 24031). https://abierto.us/counties/montgomery-county-md-24031
- City: Silver Spring. https://abierto.us/cities/silver-spring-md-2472450
- First posted: May 16, 2025
- Last posted: May 16, 2025
- SAM.gov: https://sam.gov/workspace/contract/opp/14b7a4d7b8ed403eb6f86e843e1d0964/view

## Description

The Division of Product Quality Research (DPQR) conducts research on assessing the quality and safety of drug products. One of the on-going research activities is to conduct research on assessing the performance, quality and safety of transdermal and topical drug products. These studies are critical in assessing the quality of transdermal and topical drug delivery systems.

To support this function, DPQR is requesting the acquisition of one (1) Automated Dry Heat Diffusion System with 24 vertical cells (or equivalent). This Automated Dry Heat Diffusion System will be used to perform diffusion studies that are approximately 96 hours and with large number of samples and repetitions to check the drug release and permeation across synthetic and biological barriers.

This Automated Dry Heat Diffusion System and these diffusion studies will provide valuable information regarding safety, performance, and quality of transdermal and drug products and support CDER’s mission critical missions. The Automated Dry Heat Diffusion System with 24 vertical cells is used for studying the in vitro drug release and diffusion across various synthetic and biological barriers.

This diffusion system has a heated donor and receiver compartments of the vertical diffusion cells with an automated mechanism to continuously collect and replace aliquot and whole media samples from all diffusion cells. This automated mechanism should also eliminate and expel any air bubbles that may be formed below the diffusion barrier during dosing and sampling throughout the study duration.

This Automated Dry Heat Diffusion System is also equipped with sensors for direct measurement and control of donor and receiver chambers and barrier temperatures throughout the study duration.

## Award on USAspending

- Recipient: Aantilia LLC (UEI M1WNFFFKYSX6)
- Contract: 75F40125P00087, purchase order
- Obligated: $246,067.50
- Competition: Competed Under SAP, 9 offers received
- Link: solicitation number 75F40125Q00181 equals the FPDS solicitation identifier; same awarding office 75F401 (high confidence)
- Record: https://www.usaspending.gov/award/CONT_AWD_75F40125P00087_7524_-NONE-_-NONE-/


## Publications

- May 16, 2025: Combined synopsis and solicitation, due May 30, 2025 at 2:00 PM EDT. Notice 14b7a4d7b8ed403eb6f86e843e1d0964. https://sam.gov/workspace/contract/opp/14b7a4d7b8ed403eb6f86e843e1d0964/view

## Points of contact

- Amanda Lusk, Amanda.Lusk@fda.hhs.gov
- Nicholas Bisher, Nicholas.Bisher@fda.hhs.gov

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Source: SAM.gov Contract Opportunities bulk extract and USAspending.gov award data. Confirm deadlines on SAM.gov before responding. Cite https://abierto.us/opportunities/75f40125q00181.