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Potency of the extract is determined by measuring Amb a 1 content. The Laboratory of Immunobiochemistry (LIB) needs to develop reference standard Amb a 1-specific capture and biotin-labeled detection monoclonal aptamers suitable for use in Enzyme Linked Immunosorbent Assay (ELISA)/ImmunoEnzymetric Assay (IEMA) to measure biological potencies of commercial ragweed pollen extracts marketed in the United States. 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Potency of the extract is determined by measuring Amb a 1 content. The Laboratory of Immunobiochemistry (LIB) needs to develop reference standard Amb a 1-specific capture and biotin-labeled detection monoclonal aptamers suitable for use in Enzyme Linked Immunosorbent Assay (ELISA)/ImmunoEnzymetric Assay (IEMA) to measure biological potencies of commercial ragweed pollen extracts marketed in the United States. Scope Amb a 1-specific capture and biotin-labeled detection monoclonal antibodies suitable for use in Enzyme Linked Immunosorbent Assay (ELISA)/ImmunoEnzymetric Assay (IEMA).","origin":"extract"},"notice_type":{"code":"o","label":"Solicitation"},"schema_version":1,"solicitation_number":"75F40124Q00548","place_of_performance":{"city":{"name":"Silver Spring"},"state":{"code":"MD"},"country":{"code":"USA"}},"product_service_code":"B504"},{"dates":{"posted":"2024-09-25","response_deadline":{"raw":"2024-09-27T12:00:00-04:00","utc":"2024-09-27T16:00:00Z","date":"2024-09-27","time":"12:00:00","utc_offset_seconds":-14400}},"links":{"sam":"https://sam.gov/workspace/contract/opp/d56340726c714a0194e1707063a30f69/view"},"naics":{"codes":["325414"],"primary":"325414"},"title":"Center for Biologics Evaluation and Research (CBER) DBPAP/ Amb a 1-Specific Aptamers","agency":{"office":{"code":"75F401","name":"FDA OFFICE OF ACQ GRANT SVCS"},"subtier":{"code":"7524","name":"FOOD AND DRUG ADMINISTRATION"},"department":{"code":"075","name":"HEALTH AND HUMAN SERVICES, DEPARTMENT OF"},"office_address":{"zip":"20852","city":"Rockville","state":"MD","country":"USA"},"organization_type":"OFFICE"},"status":{"active":false,"archive_date":"2024-10-12","archive_type":"auto15"},"contacts":[{"name":"Nicholas Bisher","role":"primary","email":"Nicholas.Bisher@fda.hhs.gov"}],"base_type":{"code":"o","label":"Solicitation"},"notice_id":"d56340726c714a0194e1707063a30f69","set_aside":{"code":"SBA","label":"Total Small Business Set-Aside (FAR 19.5)"},"provenance":{"extract":{"url":"https://s3.amazonaws.com/falextracts/Contract%20Opportunities/Archived%20Data/FY2024_archived_opportunities.csv","etag":"\"d582488fe153a9f11bf629913d176ffc-137\"","fetched_at":"2026-09-16T19:07:39.720164Z","row_sha256":"63458c1dc824691bb27af693a8060f8c5bb6b06bf4123a432cfa494c64504085","last_modified":"2026-09-13T14:47:40Z"},"updated_at":"2026-09-16T19:07:39.720164Z","first_seen_at":"2026-09-16T19:07:39.720164Z"},"description":{"text":"PER AMENDMENT 1 - Proposal Receipt date/time extended to 9/27/2024 at 12:00 pm EST. _________________________________________________________________________________ Introduction Development of Amb a 1- Specific capture and biotin-labeled detection Aptamers for use in Enzyme Linked Immunosorbent Assay (ELISA)/ImmunoEnzymetric Assay (IEMA) Background In the United States ragweed allergen extracts are standardized, which means that their potencies are determined in comparison to a US Reference Standard. 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