# Notice of Intent to Sole Source: West Virginia University Research Corporation Canonical: https://abierto.us/opportunities/6b1cf23e78e3448daf57aa0b2d898da2 - Solicitation number: 98769 - Notice type: Combined synopsis and solicitation - Status: Closed. Deadline was August 21, 2026 at 12:00 PM EDT - Department: Department of Health and Human Services - Agency: Centers for Disease Control and Prevention - Contracting office: CDC Office of Acquisition Services (75D301) - NAICS: 541714 Research and Development in Biotechnology (except Nanobiotechnology) - Product or service code: AJ11 General Science And Technology R&D Services; General Science And Technology; Basic Research - Place of performance: Morgantown, West Virginia - County: Monongalia County (FIPS 54061). https://abierto.us/counties/monongalia-county-wv-54061 - City: Morgantown. https://abierto.us/cities/morgantown-wv-5455756 - First posted: August 11, 2026 - Last posted: August 11, 2026 - SAM.gov: https://sam.gov/workspace/contract/opp/6b1cf23e78e3448daf57aa0b2d898da2/view ## Description Engineered stone countertops containing more than 90% crystalline silica have become increasingly popular among consumers in recent years. As a result, the rapidly growing workforce in this industry is at significant risk of a well-documented occupational hazard—overexposure to respirable crystalline silica (RCS), which can lead to progressive, irreversible, and potentially disabling pulmonary silicosis. Epidemiological studies have also linked occupational exposure to RCS with the occurrence of autoimmune diseases, including lupus erythematosus, systemic sclerosis, and rheumatoid arthritis. However, the relationship between the development of these autoimmune diseases and silica-induced inflammation and fibrosis remains unclear, and the underlying mechanisms of RCS-induced autoimmune responses have not been fully elucidated. This study hypothesizes that dust from engineered stone fabrication may cause serious health issues, especially triggering autoimmune responses. To test this hypothesis, animal studies are required. This project involves oropharyngeal aspiration studies to evaluate autoimmune responses to chronic exposure to emissions from engineered stone materials in mice. The project was initiated at CDC/NIOSH/HELD in 2024 and paused in 2025. The overall objective of this project is to evaluate the immune responses to dust released from engineered stone countertops during fabrication processes in mice to better understand worker health risks associated with these exposures. This study will employ a sensitization and challenge model to evaluate autoimmune responses following repeated exposure to engineered stone dust. To determine engineered stone dust (ESD)–induced autoimmune responses in mice, two strains of mice (NZBWF1/J and C57BL/6J) will be exposed to two ESD variants—Silestone (~90% crystalline silica) and HybriQ (~60% crystalline silica)—with evaluation at 90 days post-exposure. The study design will include two mouse strains, two ESD variants, and three exposure groups (Silestone, HybriQ, and PBS control), with 8 mice per group and a single exposure dose, followed by a 90-day post-exposure period. The total number of mice is 48 (24 NZBWF1/J and 24 C57BL/6J). ## Publications - August 11, 2026: Combined synopsis and solicitation, due August 21, 2026 at 12:00 PM EDT. Notice 6b1cf23e78e3448daf57aa0b2d898da2. https://sam.gov/workspace/contract/opp/6b1cf23e78e3448daf57aa0b2d898da2/view ## Points of contact - Kourtney Marshall, qrz9@cdc.gov, 4044984280 --- Source: SAM.gov Contract Opportunities bulk extract. Confirm deadlines on SAM.gov before responding. Cite https://abierto.us/opportunities/6b1cf23e78e3448daf57aa0b2d898da2.