{"canonical":"https://abierto.us/opportunities/36c24526q0669","key":"36C24526Q0669","url":"https://abierto.us/opportunities/36c24526q0669","title":"AJ13--Pharmarcokinetics for Experimental Rheumatoid Arthritis treatment","solicitation_number":"36C24526Q0669","notice_type":"p","open":false,"response_deadline":"2026-07-31T13:00:00Z","first_posted":"2026-07-16","last_posted":"2026-07-16","department":"VETERANS AFFAIRS, DEPARTMENT OF","subagency":"VETERANS AFFAIRS, DEPARTMENT OF","office":"245-NETWORK CONTRACT OFFICE 5 (36C245)","naics":"112990","psc":"AJ13","set_aside":null,"place_state":null,"winner":null,"award_amount":null,"publications":[{"notice_id":"53aad037adb742b6997988dc8854eeea","title":"AJ13--Pharmarcokinetics for Experimental Rheumatoid Arthritis treatment","solicitation_number":"36C24526Q0669","notice_type":"r","base_type":"r","posted":"2026-07-16","posted_at":null,"due_at":"2026-07-31T13:00:00Z","due_date":"2026-07-31","cancelled":null,"archived":null,"archive_date":"2026-09-29","award_number":null,"awardee_name":null,"amount":null,"link_sam":"https://sam.gov/workspace/contract/opp/53aad037adb742b6997988dc8854eeea/view","enriched":false,"history":[]},{"notice_id":"750f005515244b6eb709587fd0f1a412","title":"AJ13--Pharmarcokinetics for Experimental Rheumatoid Arthritis treatment","solicitation_number":"36C24526Q0669","notice_type":"p","base_type":"r","posted":"2026-07-16","posted_at":null,"due_at":"2026-07-31T13:00:00Z","due_date":"2026-07-31","cancelled":null,"archived":null,"archive_date":"2026-09-29","award_number":null,"awardee_name":null,"amount":null,"link_sam":"https://sam.gov/workspace/contract/opp/750f005515244b6eb709587fd0f1a412/view","enriched":false,"history":[]}],"latest_notice_id":"750f005515244b6eb709587fd0f1a412","first_type":"r","notices":[{"dates":{"posted":"2026-07-16","response_deadline":{"raw":"2026-07-31T09:00:00-04:00","utc":"2026-07-31T13:00:00Z","date":"2026-07-31","time":"09:00:00","utc_offset_seconds":-14400}},"links":{"sam":"https://sam.gov/workspace/contract/opp/53aad037adb742b6997988dc8854eeea/view"},"naics":{"codes":["112990"],"primary":"112990"},"title":"AJ13--Pharmarcokinetics for Experimental Rheumatoid Arthritis treatment","agency":{"office":{"code":"36C245","name":"245-NETWORK CONTRACT OFFICE 5 (36C245)"},"subtier":{"code":"3600","name":"VETERANS AFFAIRS, DEPARTMENT OF"},"department":{"code":"036","name":"VETERANS AFFAIRS, DEPARTMENT OF"},"office_address":{"zip":"21090","city":"LINTHICUM","state":"MD","country":"USA"},"organization_type":"OFFICE"},"status":{"active":true,"archive_date":"2026-09-29","archive_type":"auto_custom"},"contacts":[{"name":"Robert O'Keefe Jr.","role":"primary","email":"robert.okeefejr@va.gov","title":"Contracting Officer"}],"base_type":{"code":"r","label":"Sources Sought"},"notice_id":"53aad037adb742b6997988dc8854eeea","provenance":{"extract":{"url":"https://s3.amazonaws.com/falextracts/Contract%20Opportunities/datagov/ContractOpportunitiesFullCSV.csv","etag":"\"3f59209463433eba6899e195a597c64d-29\"","fetched_at":"2026-09-16T07:50:12.777658Z","row_sha256":"676d2d8f9cf4545f6f12541eba92eddf6396e6fec41f44beb5bb9051d9c33d9a","last_modified":"2026-09-16T03:30:52Z"},"updated_at":"2026-09-16T07:50:12.777658Z","first_seen_at":"2026-09-16T00:55:28.845070Z"},"description":{"text":"SOURCES SOUGHT NOTICE Department of Veterans Affairs Network Contracting Office (NCO) 05 Title: A Joint Targeted Drug Delivery Approach for Arthritis Therapy Toxicity and Pharmacokinetics 1. Purpose This Sources Sought Notice is issued solely for market research in accordance with FAR Part 10. This is not a solicitation, and it does not commit the Government to issue a solicitation or make an award. The Department of Veterans Affairs (VA) seeks to identify qualified vendors capable of performing preclinical toxicology and pharmacokinetic (PK) studies on an experimental Rheumatoid Arthritis treatment involving peptide-displaying liposomes containing dexamethasone. 2. Requirement Overview The VA requires a contractor to perform GLP-compliant toxicity testing and GLP or non GLP pharmacokinetic studies in adult rats. These studies support advancement toward a future FDA Pre IND meeting for the patented joint-targeted liposomal delivery system developed under prior VA-funded research. 3. Summary of Required Services A. Toxicity Studies (GLP Required) Receive peptide displaying liposomes containing 150 mg dexamethasone, 80% encapsulation efficiency, with Certificate of Analysis. Conduct single dose intravenous toxicity testing in 20 32 rats (male and female). Record clinical observations, weight, and food intake over a 14 day period. Conduct blood testing for organ damage markers (liver, kidney, heart, muscle, etc.). Perform euthanasia, necropsy, and histopathology of major organs. B. Pharmacokinetic (PK) Studies (GLP or non GLP) Administer single IV doses to 12 24 rats (balanced sexes). Observe and weigh animals before and after dosing. Collect blood samples at 8 10 defined time points (10 min through 48 hours). Process plasma and store at 20°C. Perform chemical extraction and LC MS/MS quantification of dexamethasone and metabolite 6 hydroxydexamethasone (6OHDEX). Generate PK parameters (t½, Cmax, AUC, etc.). C. Final Deliverable Comprehensive written report summarizing toxicity, PK parameters, and analytical results. 4. Place of Performance Vendor s laboratory. Toxicology tasks must be performed under GLP. PK tasks may be performed under GLP or non GLP. 5. Period of Performance 1 year of service (if necessary) September 15, 2026 September 14, 2027. 6. Requested Information from Interested Vendors Please submit the following in your capability statement: Company name, address, point of contact, phone, and email. Unique Entity Identifier (UEI) and confirmation of active SAM.gov registration. Business size and socio economic status under NAICS 325412. Demonstrated technical capability and experience performing: GLP toxicology studies Rodent PK studies LC MS/MS analysis Histopathology and necropsy Relevant past performance for biomedical R&D or FDA preclinical support. Any additional information proving capability to meet the requirements. 7. Socio Economic Categories of Interest The VA encourages responses from: SDVOSB, VOSB, 8(a), HUBZone, WOSB, Small businesses, Large businesses 8. Point of Contact for Responses Contracting Officer: Robert O Keefe Jr. Email: robert.okeefejr@va.gov Please submit all capability statements directly to the Contracting Officer for review no later than (NLT) July 29, 2026 0900 Eastern Standard Time. Your email subject line should read: Response to Sources Sought Notice Approach for Arthritis Therapy Toxicity and Pharmacokinetics (NAICS 325412 / PSC AJ13) 9. Disclaimer Upon completion of Market Research, a Confidential Disclosure Agreement (CDA) will be required of selected vendors. The CDA must be fully executed before any proprietary information is released. Selected vendors will receive exclusive access to solicitation materials and proprietary documents once the CDA is completed. This Sources Sought Notice is for market research purposes only. Information received will assist the Government in shaping the acquisition strategy. This notice does not constitute a solicitation, does not request quotes, and does not obligate the Government to issue a solicitation or award a contract.","origin":"extract"},"notice_type":{"code":"r","label":"Sources Sought"},"schema_version":1,"solicitation_number":"36C24526Q0669","place_of_performance":{"zip":"21218","street":"Contractors Lab/Facility See notice for details","country":{"code":"USA"}},"product_service_code":"AJ13"},{"dates":{"posted":"2026-07-16","response_deadline":{"raw":"2026-07-31T09:00:00-04:00","utc":"2026-07-31T13:00:00Z","date":"2026-07-31","time":"09:00:00","utc_offset_seconds":-14400}},"links":{"sam":"https://sam.gov/workspace/contract/opp/750f005515244b6eb709587fd0f1a412/view"},"naics":{"codes":["112990"],"primary":"112990"},"title":"AJ13--Pharmarcokinetics for Experimental Rheumatoid Arthritis treatment","agency":{"office":{"code":"36C245","name":"245-NETWORK CONTRACT OFFICE 5 (36C245)"},"subtier":{"code":"3600","name":"VETERANS AFFAIRS, DEPARTMENT OF"},"department":{"code":"036","name":"VETERANS AFFAIRS, DEPARTMENT OF"},"office_address":{"zip":"21090","city":"LINTHICUM","state":"MD","country":"USA"},"organization_type":"OFFICE"},"status":{"active":true,"archive_date":"2026-09-29","archive_type":"auto_custom"},"contacts":[{"name":"Robert O'Keefe Jr.","role":"primary","email":"robert.okeefejr@va.gov","title":"Contracting Officer"}],"base_type":{"code":"r","label":"Sources Sought"},"notice_id":"750f005515244b6eb709587fd0f1a412","provenance":{"extract":{"url":"https://s3.amazonaws.com/falextracts/Contract%20Opportunities/datagov/ContractOpportunitiesFullCSV.csv","etag":"\"3f59209463433eba6899e195a597c64d-29\"","fetched_at":"2026-09-16T07:50:12.777658Z","row_sha256":"f06c800af6c18fa7149376a58b9f13dea4dbde609c4565e99b62cd430fe7e0c0","last_modified":"2026-09-16T03:30:52Z"},"updated_at":"2026-09-16T07:50:12.777658Z","first_seen_at":"2026-09-16T00:55:28.845070Z"},"description":{"text":"PRE SOLICITATION NOTICE Department of Veterans Affairs Network Contracting Office (NCO) 05 Title: A Joint Targeted Drug Delivery Approach for Arthritis Therapy Toxicity and Pharmacokinetics The Department of Veterans Affairs (VA), Network Contracting Office (NCO) 05, intends to issue a solicitation for preclinical toxicology and pharmacokinetic (PK) studies to support advancement of an experimental joint targeted liposomal delivery system for Rheumatoid Arthritis therapy. This requirement involves GLP compliant toxicity studies and GLP or non GLP PK studies in adult rats. The forthcoming solicitation will seek a contractor capable of performing: GLP single dose IV toxicity studies including clinical observations, weight/food intake monitoring, blood chemistry assessments, necropsy, and histopathology. GLP or non GLP pharmacokinetic studies including IV dosing, timed blood collection, plasma processing and storage, LC MS/MS analysis of dexamethasone and 6 hydroxydexamethasone, and calculation of PK parameters. A comprehensive final written report covering toxicity results, PK data, and analytical findings. Place of performance will be the contractor s laboratory. The anticipated period of performance is one year, approximately September 15, 2026 through September 14, 2027. This notice is issued solely for informational purposes. A formal solicitation and the Government s acquisition strategy will be issued after completion of market research. This notice does not constitute a solicitation and does not commit the Government to award a contract. Point of Contact: Robert O Keefe Jr., Contract Specialist Email: robert.okeefejr@va.gov","origin":"extract"},"notice_type":{"code":"p","label":"Presolicitation"},"schema_version":1,"solicitation_number":"36C24526Q0669","place_of_performance":{"zip":"21218","street":"Contractor's Lab/Facility See Sources Sought Notice for Details","country":{"code":"USA"}},"product_service_code":"AJ13"}],"due_at":"2026-07-31T13:00:00Z","due_date":"2026-07-31","closes_at":"2026-07-31T13:00:00Z","awardable":true,"dept_key":"d-036","dept_name":"VETERANS AFFAIRS, DEPARTMENT OF","sub_key":"s-3600","sub_name":"VETERANS AFFAIRS, DEPARTMENT OF","office_key":"o-36C245","office_name":"245-NETWORK CONTRACT OFFICE 5 (36C245)","state":null,"country":"USA","winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-16T07:31:38.954589Z","principal_notice_id":"750f005515244b6eb709587fd0f1a412","description":{"text":"PRE SOLICITATION NOTICE Department of Veterans Affairs Network Contracting Office (NCO) 05 Title: A Joint Targeted Drug Delivery Approach for Arthritis Therapy Toxicity and Pharmacokinetics The Department of Veterans Affairs (VA), Network Contracting Office (NCO) 05, intends to issue a solicitation for preclinical toxicology and pharmacokinetic (PK) studies to support advancement of an experimental joint targeted liposomal delivery system for Rheumatoid Arthritis therapy. This requirement involves GLP compliant toxicity studies and GLP or non GLP PK studies in adult rats. The forthcoming solicitation will seek a contractor capable of performing: GLP single dose IV toxicity studies including clinical observations, weight/food intake monitoring, blood chemistry assessments, necropsy, and histopathology. GLP or non GLP pharmacokinetic studies including IV dosing, timed blood collection, plasma processing and storage, LC MS/MS analysis of dexamethasone and 6 hydroxydexamethasone, and calculation of PK parameters. A comprehensive final written report covering toxicity results, PK data, and analytical findings. Place of performance will be the contractor s laboratory. The anticipated period of performance is one year, approximately September 15, 2026 through September 14, 2027. This notice is issued solely for informational purposes. A formal solicitation and the Government s acquisition strategy will be issued after completion of market research. This notice does not constitute a solicitation and does not commit the Government to award a contract. Point of Contact: Robert O Keefe Jr., Contract Specialist Email: robert.okeefejr@va.gov","html":null,"origin":"extract"},"contacts":[{"name":"Robert O'Keefe Jr.","role":"primary","email":"robert.okeefejr@va.gov","title":"Contracting Officer"}],"place_of_performance":{"zip":"21218","street":"Contractor's Lab/Facility See Sources Sought Notice for Details","country":{"code":"USA"}},"office_address":{"zip":"21090","city":"LINTHICUM","state":"MD","country":"USA"},"naics_codes":["112990"],"award":null,"attachments":[],"awards":[],"related":[{"key":"36C24526Q0823","latest_notice_id":"5aa229801a35468b97136473c6d9399b","title":"Karl Storz Endoscopy Service Contract DC VAMC","solicitation_number":"36C24526Q0823","notice_type":"o","first_type":"o","first_posted":"2026-09-09","last_posted":"2026-09-09","notices":1,"due_at":"2026-09-17T15:00:00Z","due_date":"2026-09-17","closes_at":"2026-09-17T15:00:00Z","awardable":true,"open":true,"dept_key":"d-036","dept_name":"VETERANS AFFAIRS, DEPARTMENT OF","sub_key":"s-3600","sub_name":"VETERANS AFFAIRS, DEPARTMENT OF","office_key":"o-36C245","office_name":"245-NETWORK CONTRACT OFFICE 5 (36C245)","naics":"811210","psc":"J065","set_aside":null,"state":"DC","country":"USA","winner":null,"winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-16T07:31:38.954589Z"},{"key":"36C24527Q0788","latest_notice_id":"f672b179aecd43409fb305d466ae425d","title":"DME AND RELATED SERVICES","solicitation_number":"36C24527Q0788","notice_type":"o","first_type":"o","first_posted":"2026-09-08","last_posted":"2026-09-08","notices":1,"due_at":"2026-09-17T18:00:00Z","due_date":"2026-09-17","closes_at":"2026-09-17T18:00:00Z","awardable":true,"open":true,"dept_key":"d-036","dept_name":"VETERANS AFFAIRS, DEPARTMENT OF","sub_key":"s-3600","sub_name":"VETERANS AFFAIRS, DEPARTMENT OF","office_key":"o-36C245","office_name":"245-NETWORK CONTRACT OFFICE 5 (36C245)","naics":"621610","psc":"Q201","set_aside":"SBA","state":"DC","country":"USA","winner":null,"winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-16T07:31:38.954589Z"},{"key":"36C24526Q0819","latest_notice_id":"05ce94ef188f4775bf6d3ec8e750ab78","title":"Baltimore VAMC Washer/Decontamination","solicitation_number":"36C24526Q0819","notice_type":"k","first_type":"k","first_posted":"2026-09-14","last_posted":"2026-09-14","notices":1,"due_at":"2026-09-21T16:00:00Z","due_date":"2026-09-21","closes_at":"2026-09-21T16:00:00Z","awardable":true,"open":true,"dept_key":"d-036","dept_name":"VETERANS AFFAIRS, DEPARTMENT OF","sub_key":"s-3600","sub_name":"VETERANS AFFAIRS, DEPARTMENT OF","office_key":"o-36C245","office_name":"245-NETWORK CONTRACT OFFICE 5 (36C245)","naics":"339112","psc":"6515","set_aside":null,"state":"MD","country":"USA","winner":null,"winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-16T07:31:38.954589Z"},{"key":"36C24526Q0808","latest_notice_id":"1f59c5088aac483a9779ac71ee9008fb","title":"J066--|New instrument calibration","solicitation_number":"36C24526Q0808","notice_type":"k","first_type":"k","first_posted":"2026-09-15","last_posted":"2026-09-15","notices":1,"due_at":"2026-09-24T19:00:00Z","due_date":"2026-09-24","closes_at":"2026-09-24T19:00:00Z","awardable":true,"open":true,"dept_key":"d-036","dept_name":"VETERANS AFFAIRS, DEPARTMENT OF","sub_key":"s-3600","sub_name":"VETERANS AFFAIRS, DEPARTMENT OF","office_key":"o-36C245","office_name":"245-NETWORK CONTRACT OFFICE 5 (36C245)","naics":"541380","psc":"J066","set_aside":null,"state":null,"country":"USA","winner":null,"winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-16T07:50:43.959643Z"},{"key":"36C24526R0107","latest_notice_id":"09336e81ee104689b8d263c23a0b7da7","title":"C1DA--VISN 5 - INDEFINITE DELIVERY INDEFINITE QUANTITY ARCHITECT & ENGINEERING CONTRACT","solicitation_number":"36C24526R0107","notice_type":"p","first_type":"p","first_posted":"2026-07-14","last_posted":"2026-07-14","notices":1,"due_at":"2026-10-01T14:00:00Z","due_date":"2026-10-01","closes_at":"2026-10-01T14:00:00Z","awardable":true,"open":true,"dept_key":"d-036","dept_name":"VETERANS AFFAIRS, DEPARTMENT OF","sub_key":"s-3600","sub_name":"VETERANS AFFAIRS, DEPARTMENT OF","office_key":"o-36C245","office_name":"245-NETWORK CONTRACT OFFICE 5 (36C245)","naics":"541330","psc":"C1DA","set_aside":"SDVOSBC","state":null,"country":null,"winner":null,"winner_key":null,"amount":null,"linked_awards":0,"cancelled":false,"archived":false,"updated_at":"2026-09-16T07:31:38.954589Z"}]}